KnowEnG: Knowledge Network-guided analysis of genomics data on the Cloud

KnowEng

The KnowEnG Center is about to release the KnowEnG Scientific Platform—KnowEng: Knowledge Network-guided analysis of genomics data on the Cloud. This lecture will present a brief overview of the KnowEnG system from the user’s perspective, while also touching upon some of the key features of the underlying technologies.

All of the related information for the presentation via GoToMeeting on September 20 at 11am Central Time is below.

Title
KnowEnG: Knowledge Network-guided analysis of genomics data on the Cloud

Presenter
Saurabh Sinha
Professor and Willett Faculty Scholar
co-Director, KnowEnG BD2K Center of Excellence
University of Illinois, Urbana-Champaign

Date
September 20, 2017

Time
11:00 AM – 12:00 PM U.S Central Time (16:00hrs UTC)

Abstract
We have developed ‘KnowEnG’ (Knowledge Engine for Genomics, pronounced ‘knowing’), an analytics engine and cyberinfrastructure for genomics data analysis. This has been the result of research and development conducted at the BD2K Center of Excellence at the University of Illinois, in partnership with the Mayo Clinic, Rochester, MN. The KnowEnG system is deployed on a public Cloud infrastructure (currently, AWS) to provide easy access to state-of-the-art and computationally intensive genomics analysis in a scalable and decentralized manner. KnowEnG supports new as well as established machine learning algorithms and statistical methods for ‘knowledge-guided’ analysis of genomics data sets in spreadsheet form. These analyses are powered by a massive ‘knowledge network’ encoding public domain knowledge of gene properties and relationships. We have also made significant progress toward interoperability with other Cloud-based data repositories such as Cancer Genomics Cloud to provide KnowEnG’s analytical capabilities to users of those external repositories. The main driver (application) project for the technology development has been ‘cancer pharmacogenomics’ – the study of molecular mechanisms underlying cytotoxic drug response, using genomics data. We have also developed and applied new computational tools to address major problems in cancer biology and cancer treatment, as well as answer questions related to the evolution of social behavior using neurogenomics. This talk will present a brief overview of the KnowEnG system from the user’s perspective, while also touching upon some of the key features of the underlying technologies.

KnowEnG Scientific Platform 
Wed, Sep 20, 2017 11:00 AM – 12:00 PM CDT

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